Led a research team at the CINJ to the discovery of a novel experimental approach to detect genetic variations (single nucleotide polymorphisms or SNPs) that increase the risk of developing cancer and/or lower the age at which cancers may develop in some individuals. This phenomenal research and discovery, which appeared in the November 24, 2004 issue of the Journal Cell, may affect the medical community’s ability to predict the development of early onset cancers, which could mean the identification of those who should be screened at an earlier age. This discovery will not only affect women with breast cancer, but will also impact individuals with other kinds of cancer as it provides early detection, which helps in the cure of cancer. Further, this research could affect cancer treatments, as according to research these genes affect an individual’s response to varying chemotherapeutic treatments.
Dr. Levine, a resident member of The Cancer Institute of New Jersey, is also professor of pediatrics and biochemistry at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and Professor in the School of Natural Science at the Institute for Advanced Study in Princeton, NJ.